This "fix" does not require you change the graphics driver on your system. Windows 10 forces updates on you and may break things along the way. I have Windows 7 and choose to manually update my system as I feel necessary. There are three parts to the fix. 1. Limiting DEP (Data Execution Protection) only to Windows components.
I bought gta vc, gta 3 and gta sa here and in rockstar launcher, and there was same problem - i start the game, its fine, but after 1-2 minute game just stops to see the mouse, dont react on rmb or lmb. I mean, cursor moves, but it doesnt react on click. I asked about it rockstar support, but all i get was "oh, its strange, but we dont know why it happens". Maybe someone faced such a problem
Head back to the extracted MarkC Mouse Fix folder, locate your version of Windows, and open the folder. Select the registry file that corresponds with your display DPI, then double-click to import the file. Answer Yes or OK to the prompts that appear. Now reboot your system for the fix to complete.